Comparison of Phloroglucinol and Drotaverine in Accelerating First Stage of Labour

Abstract

Objective: To compare the mean duration of 1st stage of labor with phloroglucinol and drotaverine in patients with uncomplicated labour. Study design: Randomized controlled trial. Settings: Department of Obstetrics &Gynecology, Allied Hospital, Faisalabad. Duration: From 28th June, 2016 to 27th December, 2016. Methodology:80 laboring patients with singleton pregnancy, cephalic presentation, presenting at gestational age 37-40 weeks in active phase of labour were included in the study. All the females were randomly divided into two groups. In group A, phloroglucinol 40mg IV every 60 min (Maximum of 3 doses) was given and in group B drotaverine was given 40mg IV every 60 min (Maximum of 3 doses.) Duration of 1st stage of labour was measured in minutes. Results: The mean age of the patients was 27.58+4.2 years and mean gestational age was 38.09+0.97 weeks. In Phloroglucinol group, mean duration of 1st stage of labour was 154.70+26.46 min and in Drotaverine group, it was 175.30+33.34 min. There was a mean difference of 20.60 minutes between both groups and the difference was statistically significant between two groups with p-value = 0.003. Conclusion: The phloroglucinol is better than drotaverine in patients with uncomplicated labour in terms of mean duration of 1st stage of labour.