Frequency of Elevated Homocysteine Level in Patients Presented with Ischemic Stroke

Sajjad  Ali; Saima  Sheikh; Mohammad  Irfan; Rehan Anwar  Chaudhry; Sumaira  Hassan; Iqra  Waheed

doi:10.29054/apmc/2021.705

Sajjad Ali Assistant Professor, Department of Neurology, Khawaja Mohammed Safdar Medical College, Sialkot Pakistan
Saima Sheikh Assistant Professor, Department of Physiology, Khawaja Mohammed Safdar Medical College, Sialkot Pakistan
Mohammad Irfan Assistant Professor, Department of Medicine, Allied Hospital / Faisalabad Medical University, Faisalabad Pakistan
Rehan Anwar Chaudhry Assistant Professor, Department of Medicine, Khawaja Mohammed Safdar Medical College, Sialkot Pakistan
Sumaira Hassan Assistant Professor, Department of Pediatric Medicine, Faisalabad Medical University, Faisalabad Pakistan
Iqra Waheed Statistician, Lahore Pakistan

DOI: https://doi.org/10.29054/apmc/2021.705

Keywords: Elevated homocysteine level, Ischemic stroke

Abstract

Background: A stroke is the rapidly developing focal or global neurological deficit due to disturbance in the blood vessels supplying to the brain. There is increasing proof that increased homocysteine concentration may act as independent risk factor for ischemic stroke. So, this study was done to find the elevated homocysteine in stroke patients. Objective: To determine the frequency of elevated homocysteine levels in patients presenting with ischemic stroke. Study Design: Cross sectional study. Settings: Department of Neurology, Mayo Hospital, Lahore, Pakistan. Duration: Six months from March to August 2011. Methodology: Patients detailed medical history, physical examination and demographics were stored electronically, moreover the blood samples were drawn under aseptic measures within 24 hours of stroke. For each patient, homocysteine level was assessed through standard procedures from the blood. Data was analyzed through SPSS version 20 and entered in Proforma. Results: Mean age of patients was 45.09 ± 5.36 years. Majority of the patients were male. 8(8.0%) patients were 20-30 years of age, 7(7.0%) patients were between 31-40 years old and 85(85%) patients were 41-50 years of age. Elevated homocysteine level was confirmed in 56 patients (56.0%). Conclusion: Homocysteine level was found to be frequently elevated in patients with ischemic stroke.