Sensitivity Pattern for Isolates of Salmonella Typhi on Blood Culture in Children with Enteric Fever

Abstract

Background: Typhoid or Enteric fever (EF) is caused by salmonella typhi (ST) and major health concern in several developing countries. Understanding of occurrence of the ST and pattern of antibiotic sensitivity have great significance for prescription of the correct antibiotic treatment. Objective: To determine the antibiotic sensitivity pattern in children with positive blood culture for salmonella typhi. Study Design: Cross sectional study. Settings: Department of Pediatrics, Faisalabad Medical University / Allied Hospital, Faisalabad Pakistan. Duration: 1 Year from Jan 2019 to Dec 2019. Methods: 196 children age 1 – 12 years, of both gender, presenting in outpatient department (OPD) and inpatient department (IPD) with fever for ≥ 3 days were included through Non-probability consecutive sampling technique. Blood culture was sent and antibiotic sensitivity of ST isolates noted in terms of drugs sensitivity, multidrug resistance and extensively drug resistance. Data analyzed using SPSS software V.20. Results: In this study, the mean age of children was 6.15 ± 3.37 years. There were 105 (53.6%) male children while 91 (46.4%) were females children. The mean duration of fever was 5.62 ± 1.66 days. There were 127 (64.8%) children who were taking treatment for fever before presenting for culture and confirmation of typhoid fever. Total 103 (52.6%) children had drug sensitivity to antibiotics on blood culture, 44 (22.5%) had multidrug resistance (MDR) while 49 (25%) had extensively drug resistance (XDR). Conclusion: Frequency of MDR and XDR typhoid cases have significantly increased.