Effect of Raphanus sativus (Radish) Leaf Extract and High Doses of Atorvastatin on Body Weight, Liver Weight and Liver/Body Weight Ratio

Abstract

Background: Obesity is a global health problem. The chances of metabolic disorders such as type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, and atherosclerosis are increased due to obesity. Objective: (1) To determine effects of high doses of atorvastatin on body weight, liver weight and liver/body weight ratio in albino rabbits. (2) To compare the effect of three increasing doses of ethanolic extract of Raphanus sativus leaf with high doses of atorvastatin on body weight, liver weight and liver/body weight ratio in albino rabbits. Study Design: Experimental study. Settings: Department of Physiology and Pharmacology, University of Agriculture, Faisalabad Pakistan. Duration: 1 year. Methodology: The ethanolic extract of Raphanus sativus was screened for additional beneficial effects on body weight and liver weight by atorvastatin. Results: The results were compared with normal and experimental control by measuring body weight and liver weight after 28 days. There was a very highly significant reduction in weight in all groups when compared with the negative control group A. when compared to the positive control group B no significant change was observed in group C, D and E. The liver weight decreased when Raphanus sativus was added to atorvastatin and a significant effect was seen in in group E. Conclusion: Atorvastatin in high doses decreased the body weight but the combined use of Raphanus sativus and atorvastatin had no significant effect regarding liver weight addition of Raphanus sativus showed a decrease in weight of liver while an increase was seen with atorvastatin alone.