Resistance Pattern of Clinical Isolates of Enterococcus SPP. Against Vancomycin and Various Selected Antimicrobials Over 4 Years in A Multicenter Tertiary Care Hospital in Karachi

Abstract

Background: Vancomycin is a glycopeptide antimicrobial usually reserved to serious and ampicillin resistant enterococcal infections. However, the emergence and propagation of vancomycin resistant enterococci (VRE) is becoming a serious threat to the lives since only limited choices are available to treat VRE infections. Previous reports on VRE in Pakistan have shown an increasing resistance of enterococci against many antimicrobial. In this study we have assessed the susceptibility pattern of enteroccoci against vancomycin and various other antimicrobials in the last 4 years. Setting: clinical laboratories of a multicenter tertiary care hospital in Karachi. Period: from the year 2012 to 2015 Methods: 3192 samples of Enterococcus species were reviewed for susceptibility against antimicrobials. Results: A total of 3192 samples were collected during this period, of this it was observed that vancomycin have antibiogram of 11 % with a sudden rise in 2014 to 15% and then a 13% resistant was observed in 2015. An alarming emerging resistance was seen against ampicillin and erythromycin and chloramphenicol as well whereas no resistance was observed against linezolid. Conclusion: The study showed high level of VRE along with high level of resistance against other antimicrobials. It is essential to determine and control the factors responsible for this augmentation of VRE