Comparison of Wound Healing with ‘Autologous Platelet-Rich Plasma’ versus Conventional Dressing in Chronic Diabetic Foot Ulcer

Wound Healing with Autologous Platelet-Rich Plasma

Abstract

Background: Innovative approaches, such as cellular therapies like platelet-rich plasma (PRP), are emerging to enhance wound healing in diabetic foot ulcers. Objective: To compare the effectiveness of autologous PRP with conventional dressing for chronic diabetic foot ulcers. Study Design: Randomized controlled trial. Settings: Allied Hospital, Faisalabad Pakistan. Duration: January 2024 to June 30, 2024. Methods: 124 diabetic patients aged 18- 80 with non-healing foot ulcers were included. Exclusions were made for those with bleeding disorders, uncontrolled diabetes (HbA1c > 9), and severe infections, among others. Group A received PRP treatment, while Group B underwent conventional dressing. The wound area was measured weekly for 3 weeks. Results: Mean age was similar between groups (Group A: 52.92 ± 9.21 years; Group B: 52.63 ± 9.86 years). Most patients (70.97%) were aged 46 to 80. Out of 124 patients, 37.90% were male, and 62.10% were female. PRP showed an efficacy of 88.71%, compared to 67.74% for conventional dressing, with a p-value of 0.0034. Conclusion: Platelet-rich plasma is more effective than normal saline dressing for treating chronic diabetic foot ulcers.