Study of Association of Serum Lipids with Diabetic Retinopathy in Type 2 Diabetes Mellitus

  • Rabia Aftab House Officer, Department of ENT, Shaikh Zayed Hospital, Lahore Pakistan
  • Afaq Naeem House Officer, Department of Medicine, Jinnah Hospital, Lahore Pakistan
  • Sharoon Sabir Ex House Officer, Department of Medicine, Shaikh Zayed Hospital, Lahore Pakistan
  • Muhammad Kashif Azeem Ex House Officer, Department of Medicine, Shaikh Zayed Hospital, Lahore Pakistan
  • Muhammad Umer House Officer, Department of Medicine, Shaikh Zayed Hospital, Lahore Pakistan
  • Ghazanfar Zulfiqar House Officer, Department of Orthopedic, Shaikh Zayed Hospital, Lahore Pakistan
Keywords: Diabetic retinopathy, Triglycerides, Low density lipoprotein, Total cholesterol, Serum lipid, Type 2 diabetes mellitus

Abstract

Background: About 10% of diabetic people are at risk for developing diabetic retinopathy (DR), a leading cause of blindness globally. Objective: To compare serum lipid level in T2DM patients with vs. without retinopathy in population of Pakistan. Study Design: It was a randomized controlled trial. Settings: This study was carried out at Jinnah Hospital, Lahore Pakistan. Duration: Eight months from 17/2/2020 to 17/10/2020. Methods: Patients with type 2 diabetes were split into two groups: patients without diabetic retinopathy DR (Group-I) and those with diabetic retinopathy DR (Group-II). Measurements were taken of HDL, LDL, total cholesterol and TG in the serum. Results: 100 patients in total, with ages ranging from 31 to 70 for both sexes and a mean age of 56.20 ± 7.75. The gender distribution of the study participants revealed that males were more than females by a ratio of 1:1, with 43% of the patients being of the female sex and 57% of the patients being male. Serum lipid mean values for subjects with vs. without DR are compared. The mean total cholesterol for those with DR is 249 ± 27.04, while the mean for those without DR is 213 ± 43.03. As a result of DR, serum HDL levels are lower, with a mean of 41.94 ± 5.87 compared to 49.6 ± 9 9.31 in people without DR. Conclusion: A positive correlation between elevated serum lipids (Triglycerides (TG), Low Density Lipoprotein (LDL), Total Cholesterol (TC) has been established and also high serum lipid levels have also been proposed as a risk factor for DR.

Published
2022-09-30
How to Cite
Aftab, R., Naeem, A., Sabir, S., Azeem, M. K., Umer, M., & Zulfiqar, G. (2022). Study of Association of Serum Lipids with Diabetic Retinopathy in Type 2 Diabetes Mellitus. Annals of Punjab Medical College, 16(3), 172-175. https://doi.org/10.29054/apmc/2022.1087