Comparison of Behaviour Therapy versus Combination Therapy, Solifenacine with Behaviour Therapy in the Management of the Nocturnal Enuresis

Behaviour Therapy vs Solifenacin Combination with Behaviour Therapy in Nocturnal Enuresis Management

Abstract

Background: Nocturnal enuresis (NE), known as bedwetting, is a common problem with psychosocial challenges, if not properly managed, defined as the involuntary urine leakage during sleep. Objective: Outcomes comparison in the management of behaviour therapy VS combination therapy, solifenacin with behavioural-therapy in children with bedwetting. Study Design: Randomized-controlled trial. Settings: Departments of Paediatric Urology, Children's Hospital, Faisalabad Pakistan. Duration: Six months (01-04-2025 to 30-09-2025). Methods: The study was conducted with a comparison of two groups: group A consisted of patients with behaviour therapy management alone in NE, while group B consisted of patients managed with combination therapy, Solifenacin with behaviour therapy. Results: The mean wet nights were decreased in group A (only behaviour therapy) to 2.1 ± 1.4 nights/week, while in group B (1.3 ± 1.1 nights/week) were documented when patients took solifenacin with behaviour therapy. The reduction was significantly greater in the solifenacin group compared to behaviour-therapy (p=0.02). Treatment response of group-A 35% achieved complete recovery, 40% had partial recovery, and 25% had no recovery. In comparison with group B, solifenacin with behaviour therapy group have 50% complete recovery, 35% achieving partial recovery, and 15% showed no recovery. Although the complete recovery rate was higher in group B, the difference did not have strong statistical significance (p = 0.08). Conclusion: Both treatments, only behaviour therapy and a combination of Solifenacin with behaviour therapy, make the patient dry during sleep. Combination therapy has superior short-term efficacy and compliance. While the behaviour therapy alone has lower recurrence and less pharmacological side-effects.