Prevalence of Vitamin D Deficiency in Hepatitis C Patients

Abstract

Objective: The objective of this study was to compare the vitamin D levels between HCV negative individuals and HCV positive patients. Study design: Randomized cross-sectional study. Settings: Dar-us-Shifa clinic, Faisalabad. Duration: 20 August, 2017 to 20 February 2018. Methodology: The patients were divided into two classes; control group comprised of 23 individuals who were sero-negative for anti-HCV antibody and 51 patients were hepatitis C RNA-PCR positive. HCV RNA–PCR was detected by ARTUS ® HCV QS-RGQ V1 by QIAGEN GmbH on Rotor –Gene Q5 Plex – MDx. Vitamin D levels were measured by chemiluminescence. SPSS version 20 was used for statistical analysis. Results: Out of 74 patients, both male and female, 53(71.6%) patients had Vitamin D deficiency irrespective of HCV sero-negative or positive. 40(78.6%) of chronic hepatitis C patients had Vitamin D deficiency.18(35.3%) of CHV patients, had severe vitamin D deficiency, 14(27.5%) had moderate vitamin D deficiency, 8(15.7%) had mild deficiency. 13 of HCV negative participants had mild to moderate vitamin D deficiency too. Mean vitamin D level of control group was 30.4 ng/mL (normal)and 25.08 ng/mL in HCV patients. Conclusion: Most of the patients having chronic hepatitis C suffer from vitamin D deficiency or insufficiency. The mean vitamin D value was in the optimal range in HCV negative individuals, in the suboptimal range or deficient in the HCV positive patients. The results were non-significant Vitamin D,