Hypolipidemic and Protective Effects of Salvia hispanica (Chia Seed) Extract in Diet-Induced Hyperlipidemic Mice

Abstract

Objective: To evaluate the hypolipidemic effects of Salvia hispanica (chia seed) extract in Swiss albino mice subjected to diet-induced hyperlipidemia.

Methods: Mice were divided into normal control, hyperlipidemic control, drug-treated, and chia extract-treated groups (200 mg/kg and 400 mg/kg). Chia seed extract was administered for 45 days. Serum lipid profiles, body weight changes, and histopathological evaluations of liver and heart tissues were assessed.

Results: Administration of 400 mg/kg chia extract significantly reduced total cholesterol (84.32 mg/dL), triglycerides (103.71 mg/dL), LDL-C, and body weight compared to hyperlipidemic controls. No toxicity signs were observed.

Conclusion: Chia seed extract demonstrates lipid-lowering and protective effects without toxicity, supporting its potential as a natural remedy for hyperlipidemia.