Relationship between Mean Platelet Volume and Disease Activity Score in Patients Presenting with Rheumatoid Arthritis

Abstract

Background: Rheumatoid arthritis (RA) is a chronic inflammatory disorder characterized by the presence of joint inflammation, joint pain, and the progressive deterioration of synovial joints. As a consequence, individuals have physical impairment and an increased susceptibility to premature death. Objective: In order to determine the correlation between mean platelet volume and disease activity score in individuals diagnosed with rheumatoid arthritis. Study Design: Cross sectional study design. Settings: Department of Rheumatology Sheikh Zayed Hospital, Lahore Pakistan. Duration: 6th October 2021 to 5th April 2022. Methods: In this research, 140 participants of varying genders, aged between 20 and 70 years, were included, all of whom were diagnosed with rheumatoid arthritis. To evaluate disease activity, the researchers utilized the Disease Activity Score (DAS-28), and the mean platelet volume (MPV) was measured through routine complete blood examination. Results: The patient cohort spanned from 20 to 70 years old, with an average age of 45.85 ± 12.24 years. Among them, 33 (23.6%) were male, and 107 (76.4%) were female, resulting in a female-to-male ratio of 3.2:1. The duration of rheumatoid arthritis varied from 6 to 72 months, averaging 38.36 ± 16.93 months. Patients' DAS-28 scores ranged from 2.6 to 10.0, with a mean of 5.52 ± 2.10, while their mean platelet volume (MPV) ranged from 6.5 fl to 13.5 fl, with an average of 9.99 ± 1.98 fl. Conclusion: There was significantly strong negative correlation between disease activity score and mean platelet volume in patients suffering from rheumatoid arthritis across all age and gender groups.