The Precautionary Role of Ajwa Date on Hepatotoxicity Induced by Anti-Tubercular Drugs

Muhammad Shahzad  Farooq; Sadia  Majeed; Rukhshan  Khurshid; Saima  Tabassum; Bushra  Shaheen; Huma  Ashraf

doi:10.29054/apmc/2023.1366

Muhammad Shahzad Farooq Professor, Department of Biochemistry, Abwa Medical College, Faisalabad Pakistan
Sadia Majeed Assistant Professor, Department of Pharmacology, Continental Medical College, Lahore Pakistan
Rukhshan Khurshid Assistant Professor, Department of Biochemistry, Shalamar Medical & Dental College, Lahore, Pakistan
Saima Tabassum Assistant Professor, Department of Physiology, Niazi Medical & Dental College, Sargodha Pakistan
Bushra Shaheen Professor, Department of Biochemistry, Abwa Medical College, Faisalabad Pakistan
Huma Ashraf Associate Professor, Department of Biochemistry, CMH Medical & Dental College, Lahore Pakistan

DOI: https://doi.org/10.29054/apmc/2023.1366

Keywords: Anti-tubercular drug, Ajwa date, Liver enzymes, Liver injury

Abstract

Background: Anti-tubercular drugs are known to causes hepatic injury, leading to stop the medical treatment by people globally. Ajwa data as herbal medicine may help in hepatic recovery. Objective: To find the precautionary of Ajwa date on hepatotoxicity induced by anti-tubercular drugs in rabbits. Study Design: Experimental study. Settings: Department of Pharmacology, Post Graduate Medical Institute, Lahore Pakistan. Duration: One year from June 2018-June 2019. Methods: Thirty rabbits were divided into five groups (A, B, C, D & E). Two groups (A, B) were on normal diet and drugs. Three groups (C, D & E) were on drug + Ajwa(seed/flesh) for 14 days. Hepatotoxicity was confirmed by liver enzymes (ALT & AST) and by histopathology of liver tissue. Results: Level of ALT and AST were in normal limits in all groups at the start of experiment. Significant hepatotoxicity was seen after 2 weeks of orally given INH and rifampicin in group B as compared to healthy control group A. Using of Ajwa date during the same period decreased the high levels of enzymes in groups C, D and E and brings liver function normal like healthy controls. Histological findings showed that after the administration of Ajwa, its flesh and powder, the changes of liver structure like degeneration, steatosis, necrosis etc. are relieved. Conclusion: Co-administration of Ajwa date along with its constituents are parallel and effective in reducing isoniazid and rifampicin induced hepatotoxicity.