Vitamin D level among Patients of Inflammatory Bowel diseases and its Correlation with Severity of Disease

  • Sana Jawad Resident, Department of Physiology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
  • Salma Farukh Memon Professor, Department of Physiology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
  • Aijaz Ahmed Shaikh Assistant Professor of Surgery, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
  • Shakil Ahmed Shaikh Assistant Professor, Department of Physiology, Suleman Roshan Medical College Tando Adam, Pakistan
  • Arsalan Ahmed Uqaili Assistant Professor, Department of Physiology, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan
  • Aamir Hussain Associate Professor, Department of Physiology, BMC, LUMHS / Jamshoro, Pakistan
Keywords: Vitamin D, Deficiency, IBD

Abstract

Background: Inflammatory bowel diseases (IBD) are the chronic, disabling illnesses causing inflammation and ulceration all over the gastro-intestinal tract. Vitamin D plays an important role in the regulation of inflammatory immune responses, the surveillance of the microbiota in the gut, and the protection of the stability of the gastrointestinal mucosa. Objective: To determine the vitamin D levels in patients with inflammatory bowel diseases and its correlation with the severity of the disease. Study Design: Cross-sectional study. Settings: Physiology department LUMHS/ Jamshoro with collaboration Surgery and Gastroenterology departments of LUMHS Jamshoro, Pakistan. Duration: November 2021–May 2022. Methods: Diagnosed cases of inflammatory bowel diseases (IBD), both Ulcerative colitis and Crohn`s disease, meeting the criteria were included. A 5 mL blood sample was taken from each case to assess the vitamin D level. All the information was collected through the use of a study proforma, and the analysis was performed with the SPSS programmed 26.0. Results: A total of 60 patients with inflammatory bowel diseases were studied, their average age was 35.66 ± 4.55 years. Out of study participates, the males were 60.0% and females were 40.0%. 43.3% of the cases had mild disease, 43.3% had moderate disease, and 13.4% had severe disease. Most of the cases 73.3% had moderate deficiency, 13.3% of study participants had mild deficiency, and 13.3% of cases had severe deficiency. Vitamin D deficiency was found to be statistically significant according to gender (p = 0.059), and there was a statistically significant association between vitamin D deficiency and disease severity (p = 0.002). Conclusion: The deficiency of vitamin D was observed to be highly prevalent among patients with inflammatory bowel diseases.

Published
2023-01-30
How to Cite
Jawad, S., Memon, S. F., Shaikh, A. A., Shaikh, S. A., Uqaili, A. A., & Hussain, A. (2023). Vitamin D level among Patients of Inflammatory Bowel diseases and its Correlation with Severity of Disease. Annals of Punjab Medical College, 16(3), 216-219. https://doi.org/10.29054/apmc/2022.1360