Vitamin D Deficiency in the Patients of Diabetes Mellitus and Its Correlation with HbA1c

Anwar Ali  Jamali; Nadeem Ahmed  Memon; Ubaid  Rabbani; Komal  .; Abdul Karim  Soomro; Syed  Jahanghir

doi:10.29054/apmc/2023.1342

Anwar Ali Jamali Professor of Medicine, Peoples University of Medical & Health Sciences for Women, Nawabshah Pakistan
Nadeem Ahmed Memon Assistant Professor, Department of Medicine, Muhammad Medical College, Mirpurkhas Pakistan
Ubaid Rabbani Post Graduate Resident, Department of Medicine, Isra University Hospital, Hyderabad Pakistan
Komal . Medical Officer, Peoples University of Medical & Health Sciences for Women, Nawabshah (SBA) Pakistan
Abdul Karim Soomro Associate Professor, Department of pathology, Bilawal Medical College, Jamshoro, Pakistan
Syed Jahanghir FCPS Resident, Department of Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, Pakistan

DOI: https://doi.org/10.29054/apmc/2023.1342

Keywords: Type-2 Diabetes mellitus, Vitamin D, Hba1c

Abstract

Background: Diabetes mellitus is a prevalent chronic metabolic disorder. Elevated HbA1c levels are associated with a higher risk of diabetes-related complications. Some studies have suggested a potential correlation between vitamin D levels and HbA1c, indicating that vitamin D deficiency may contribute to poor glycemic control. Objective: To evaluate the vitamin d deficiency in the patients of type-II diabetes mellitus and its correlation with HbA1c. Study Design: Cross-sectional study. Settings: Department of Medicine, PUMHS Nawabshah and MMC MirpurKhas Pakistan. Duration: 6 months of period from July 2021 to December 2021. Methods: Study included patients with type 2 diabetes mellitus, aged over 40 years and both genders. A 5ml blood sample was collected from each participant after obtaining informed consent and sent to the diagnostic laboratory to determine the HbA1c levels and vitamin D status. Data collection was carried out using a self-made study proforma, and the data were analyzed using SPSS version 26. Results: A total of 58 diabetes patients were evaluated for vitamin D deficient and its correlation with HbA1c. Overall mean age of the patients was 53.32 ± 8.54 years. Males were 28(48.3%) and females were 30(51.7%). Most of the patients 48.30% had moderately decreased vitamin D level, followed by 25.90% cases had mild deficiency, only one case had severely decreased vitamin D level. There was a significant negative correlation between vitamin d level and HbA1c (r= - 0.314) (p= 0.016). Conclusion: Among individuals with type 2 diabetes mellitus, there was a higher prevalence of vitamin D deficiency and insufficiency. Additionally, a significant inverse relationship was observed between vitamin D deficiency and HbA1c levels.