Reduction of Body and Testicular Weight of Albino Rats in Arsenic Toxicity

Mujahid Akbar Mamoun; Sajid Muneer Qazi; Irum  Alamgir

doi:10.29054/apmc/2018.98

Mujahid Akbar Mamoun Associate Professor, Anatomy Quaid-E-Azam Medical College, Bahawalpur
Sajid Muneer Qazi Senior Demonstrator, Anatomy Quad-e-Azam Medical College, Bahawalpur
Irum Alamgir Senior Demonstrator, Anatomy Quad-e-Azam Medical College, Bahawalpur

DOI: https://doi.org/10.29054/apmc/2018.98

Keywords: Arsenic, Toxicity, Body and Testicular Weight

Abstract

Abstract: The metals toxic for living being are led, mercury, arsenic, cadmium and cobalt. Arsenic is increasing day by day in underground water and is more toxic for the proliferating tissue in the body as intestine, ovaries, testes etc. Study design: Experimental study. Place and duration: National Institute for health, Islamabad from 2008 to 2014.Methodology: 20 Male albino rats were bought from National Health Institute, Islamabad weighing from 250-300 grams. They were divided in to two groups A and B each having 10 animals. Group A was taken as control and was given 10 ml of distilled water orally in the morning and evening with normal diet for 28 days. Group B was given 10 ml of water with sodium arsenite 5mg/kg of body weight for 28 days with normal diet. Results: The present study showed that there was reduction of body and testicular weight of albino rats given arsenic when compared with control. Conclusion: Arsenite and arsenate compounds are highly toxic to human beings as well as animals. Arsenic induced toxicity might be responsible for regression of testes and reduces the body and testicular weight of albino rats.