The Effect of Oral Gabapentin used as Preemptive Analgesia to Attenuate Post Operative Pain in Patients undergoing Maxillofacial Surgeries

Sara Haider  Malik; Farah  Naz; Suresh  Kumar; Muhammad Nazir  Awan; Nighat  Mirza; Muhammad Tariq  Shah

doi:10.29054/apmc/2022.947

Sara Haider Malik Consultant Anesthetist, Fauji Foundation Hospital, Rawalpindi Pakistan
Farah Naz Assistant Professor, Department of Anesthesia, (PIMS) Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad Pakistan
Suresh Kumar Associate Professor, Department of Anesthesia, (PIMS) Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad Pakistan
Muhammad Nazir Awan Assistant Professor, Department of Anesthesia, Islamic International Medical College, Rawalpindi Pakistan
Nighat Mirza Resident Anesthesiology, Department of Anesthesia, (PIMS) Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad Pakistan
Muhammad Tariq Shah House Officer, Ayub Teaching Hospital, Abbottabad Pakistan

DOI: https://doi.org/10.29054/apmc/2022.947

Keywords: Gabapentin, Maxillofacial surgery, Pain scores, Patient satisfaction

Abstract

Background: Gabapentin was used as an anticonvulsant drug but has now shown to have analgesic effects. Some patients develop chronic postsurgical pain, which lasts for months and there are no other causes to which the pain can be attributed. Therefore, pain control in post-op patients is of critical importance and multimodal analgesic practices are gaining trend. Objective: To determine the effect of oral gabapentin given pre-operatively on post-operative pain in patients undergoing maxillofacial surgeries. Study Design: Randomized controlled trial. Settings: Department of Anesthesia, Ayub Teaching Hospital, Abbottabad Pakistan. Duration: Six months from January 2019 to June 2019. Methods: All the patients aged 20 to 70 years who were categorized as physical status I or II according to the American Society of Anesthesiologists (ASA), and were scheduled to have maxillofacial procedures that were expected to last between 120 and 180 minutes were included. Participants were divided into 2 different groups randomly: Group A received gabapentin 600 mg and Group B received placebo two hours preoperatively. The pain score was noted at 0, 2, 6, and 12 hours and patient satisfaction was observed at 24 hours post-operatively. Data collection was done by using a study proforma and analysis was done by using SPSS version 26. Results: Patients in Group A (Gabapentin group) had statistically significant results (p-value <0.05) at 0, 2, 6 and 24 hours for post-operative analgesia. Patient satisfaction was found in 90.0% of patients of gabapentin group as compared to placebo group. Conclusion: Single oral dose of gabapentin given preoperatively was observed to be the effective for post operative analgesia and decreased rescue analgesia consumption.