Antioxidant Enzyme Activity and Malondialdehyde Concentration in Patients with Urticaria Induced By Non Steroidal Anti-Inflammatory Drugs

Amna  Mushtaq; Muhammad Nasrullah Khan; Riffat  Khursheed; Muhammad Saeed Qureshi; Arif  Malik; Sara  Zahid; Abdul  Manan; Salma  Aslam; Mamoona  Munir; Mahwish  Arooj; Mahmood Hussain Qazi

doi:10.29054/apmc/2012.435

Amna Mushtaq Institute of Molecular Biology and Biotechnology The University of Lahore-Pakistan
Muhammad Nasrullah Khan Associate Professor Biochemistry Allama Iqbal Medical College, Lahore
Riffat Khursheed Associate Professor Biochemistry RMC Rawalpindi
Muhammad Saeed Qureshi Demonstrator Allama Iqbal Medical College, Lahore
Arif Malik Institute of Molecular Biology and Biotechnology The University of Lahore-Pakistan
Sara Zahid Institute of Molecular Biology and Biotechnology The University of Lahore-Pakistan
Abdul Manan Institute of Molecular Biology and Biotechnology The University of Lahore-Pakistan
Salma Aslam Institute of Molecular Biology and Biotechnology The University of Lahore-Pakistan
Mamoona Munir Institute of Molecular Biology and Biotechnology The University of Lahore-Pakistan
Mahwish Arooj Centre for Research in Molecular Medicine The University of Lahore-Pakistan
Mahmood Hussain Qazi Centre for Research in Molecular Medicine The University of Lahore-Pakistan

DOI: https://doi.org/10.29054/apmc/2012.435

Keywords: Urticaria, NSAIDs, Antioxidant enzymes activity, Malondialdehyde (MDA)

Abstract

Objective: The Urticaria caused by NSAIDs was studied for their antioxidant enzyme activity and malondialdehyde (MDA) concentration. Methodology: Patients were divided into two groups; group one act as a control and the remaining group was urticaria patients. The levels of the Thiobarbituric acid reactive substances (TBARS, as a marker of lipid peroxidation), superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT) in the serum were estimated. The enzymatic activity was estimated and compared with different categories of NSAIDs. Results: In present study CAT, SOD and lipid peroxidation product (MDA) were statistically different from that of healthy control and showed significant changes (p< 0.05) while GSH showed a non-significant (p>0.05) value. Conclusion: It is concluded that antioxidative system of the body is accelerated and shows variations in the patient of Urticaria. Moreover, present study shows the co-ordinated enzymatic mechanism and the interrelationship between enzymatic activities in allergy.