Thyroid Dysfunction in High Risk Pregnancies

Abstract

Objective: Frequency of thyroid dysfunction in high risk pregnancies. Settings: Department of Obstetrics and Gynecology, Allied Hospital Faisalabad. Study design: Cross-sectional study. Duration of study: 16-06-2014 to 15-12-2014. Methodology: A total of 245 patients were included in this study. On the basis of TSH, T3, T4 reports thyroid dysfunction (hypothyroidism/hyperthyroidism) was observed. Results: Mean age of the patients was 29.43±5.21 years. Mean gestational age was 36.45±2.72 weeks. Thyroid dysfunction was observed in 63 patients (25.7%). Out of theses 63 cases, Hypothyroidism fond in 44 (69.9%) and Hyperthyroidism in 19 patients (30.1%). High risk pregnancy factors were IUGR in 85 patients (34.7%), GDM in 100 patients (40.8%), preeclampsia in 52 patients (21.2%) and IUFD in 8 cases (3.3%). Distribution of high risk pregnancy factors in cases of thyroid dysfunction (n=63) were as follows: IUGR in 17 cases (27.0%), GDM, 20 cases (31.7%), preeclampsia in 18 cases (28.6%). IUFD in 8 cases (12.7%). Stratification of effect modifiers was carried out. Conclusion: The rate of thyroid dysfunction is increased in pregnant women with high-risk pregnancy. Under the currently recommended screening method, the majority of thyroid dysfunctions may be missing. With a full awareness of high incidence of thyroid dysfunction in pregnant women with obstetrical or medical complications, consideration should be given regarding the screening efficiency during pregnancy.