Frequency and Associated Factors of Lipohypertrophy in Children and Adolescent with Type 1 Diabetes in a Single Tertiary Care Centre

Frequency and Associated Factors of Lipohypertrophy in Children & Adolescent with Type 1 Diabetes

Abstract

Background: Type 1 diabetes mellitus (T1DM) is a disorder characterized by insulin insufficiency caused by the autoimmune destruction of pancreatic beta cells. Optimum control of TIDM needs insulin administration along with intensive education. Lipohypertrophy is one of the complications and risk factors of uncontrolled diabetes. Objective: To determine the frequency and associated factors of lipohypertrophy in children and adolescents with type 1 diabetes in a single tertiary care centre. Study Design: Cross-sectional descriptive study. Settings: Department of Pediatric Endocrinology and Diabetes, Pediatric Unit-1, FMU/Allied Hospital, Faisalabad, Pakistan. Duration: 6 months from January 2023 to June 2023. Methods: A total of 148 children and adolescents with type 1 diabetic patients were enrolled. All the children were examined for the presence of lipohypertrophy (LH), and different associated factors for lipohypertrophy were statistically assessed to determine its significance. Results: The mean age of children and adolescents with type 1 diabetes was 6.74 ± 2.67 years (3 to 12 years). Males and females were 85 (57.43%) and 63 (42.57%), respectively. The frequency of lipohypertrophy was found in 58/148 (39.19%) patients with male predominance (40/85). Failure to change the injection sites and the younger age group were the most important associated factors for lipohypertrophy. Conclusion: The frequency of lipohypertrophy (LH) is high among children and adolescents with T1DM. The most important associated factors for lipohypertrophy were the younger age group, failure to change the injection sites, syringe reuse, and poor diabetes control.