Relationship of Endometriosis with Cortisol and Thyroid Function in Young Working Females

Endometriosis in Young Working Females with Hormone Dysfunction

  • Iram Qamar Professor, Department of Physiology, Rahbar Medical & Dental College, Lahore Pakistan
  • Saima Mukhtar Associate Professor, Department of Physiology, Rahbar Medical & Dental College, Lahore Pakistan
  • Mah E Jabeen Assistant Professor, Department of Physiology, Rahbar Medical & Dental College, Lahore Pakistan
  • Sara Naeem Assistant Professor, Department of Physiology, Rahbar Medical & Dental College, Lahore Pakistan
  • Javeria Latif Associate Professor, Department of Physiology, CMH Institute of Medical Sciences, Bahawalpur Pakistan
  • Shaista Hussain Associate Professor, Department of Physiology, RLKU Medical College, Lahore Pakistan
Keywords: Thyroid hormones, Endometriosis, Hypothyroidism, Estrogen

Abstract

Objective: The study was focused to evaluate the role of endometriosis in development of hypothyroidism in working females subjected to chronic stress. Study Design: cross sectional study. Settings: This research was conducted at department of Gynecology & Obstetrics, The University of Lahore Teaching Hospital, Lahore. Duration: The research was completed in from February 2023 to February 2024.  Methods: Serum samples of fifty-five endometriosis patients and fifteen controls were analyzed for T3, T4, TSH, cortisol and estrogen levels by using ELISA kits. Results: The levels of TSH in patient’s serum is (1.02±0.168mIU/L) as related to control (3.08±1.090 mIU/L) were lower in females with endometriosis. Serum estrogen levels in endometriosis patients (67.07±5.54 pg/ml) were higher than normal controls (21.07±3.66pg/ml). Elevated levels of serum cortisol (27.25±3.27) than normal values (11.19±4.18) in endometriosis patients were observed.  Thyroid problems may result from this imbalance. Furthermore, there is a change in the quantity of thyroid hormones (T3 and T4) in endometriotic cells. Production of T4 rose whereas that of T3 fell. Thus, our research shows that endometriosis increases the risk of thyroid malfunction and hormone imbalance in women. Conclusion: We came to the conclusion that thyroid hormone contributes to endometriosis because endometrial cells are sensitive to changes in TSH. The thyroid gland and its related hormone concentrations described a varied picture between healthy subjects and patients of endometriosis.  Moreover, thyroid hormones and estrogen are found to play their significant roles in the disease.

Published
2024-03-31
How to Cite
Qamar, I., Mukhtar, S., Jabeen, M. E., Naeem, S., Latif, J., & Hussain, S. (2024). Relationship of Endometriosis with Cortisol and Thyroid Function in Young Working Females: Endometriosis in Young Working Females with Hormone Dysfunction. Annals of Punjab Medical College, 18(1), 11-15. https://doi.org/10.29054/apmc/2024.1581