Comparison of Ondansetron and Granisetron in Prevention of Post-Operative Nausea and Vomiting Following Laparoscopic Cholecystectomy

Riffat  Saeed; Hasnain Ameer  Hamza; Asma  Liaqat; Muhammad  Safdar; Muhammad  Idrees; Alia  Rehman

doi:10.29054/apmc/2023.1216

Riffat Saeed Assistant Professor, Department of Anesthesia, Sheikh Zayed Hospital, Lahore Pakistan
Hasnain Ameer Hamza Assistant Professor, Department of Anesthesia, Farooq Hospital, Islamabad Pakistan
Asma Liaqat Senior Registrar, Department of Anesthesia, Lahore General Hospital Lahore Pakistan
Muhammad Safdar Medical Officer, Sheikh Zayed Hospital, Lahore Pakistan
Muhammad Idrees Consultant Anesthetist, Department of Anesthesia, Abbas Institute of Medical Sciences, Muzaffarabad AJK Pakistan
Alia Rehman Assistant Professor, Department of Pharmacology, Mohtarma Benazir Bhutto Shaheed Medical College, Mirpur Azad Kashmir Pakistan

DOI: https://doi.org/10.29054/apmc/2023.1216

Keywords: Laparoscopic, Cholecystectomy, Ondansetron, Granisetron, Post-operative nausea and vomiting

Abstract

Background: The unpleasant negative consequences of general anesthesia, such as nausea or vomiting (PONV), are often encountered during laparoscopic procedures. Patients having laparoscopic cholecystectomy under general anesthesia were studied to determine the relative effectiveness of the antiemetic drugs ondansetron and granisetron, both of which target the 5-hydroxytryptamine-3 receptor. Objective: The primary objective of this research is to compare the effectiveness of granisetron and ondansetron in preventing post-operative nausea and vomiting (PONV) in patients with laparoscopic cholecystectomy. Study Design: Randomized, prospective study. Settings: This study was conducted at Department of Anesthesiology Shaikh Zayed Hospital, Lahore Pakistan. Duration: February 2022 to July 2022. Methods: Sixty patients between the ages of 20 and 60 with ASA-PS I/II and body masses of 40 to 80 kg were enrolled in this study of laparoscopic cholecystectomy performed under general anesthesia. There was a total of sixty patients, with thirty patients assigned to Group I (Ondansetron 4mg intravenously) and 30 patients assigned to Group II (Granisetron 2mg intravenously). Both medicines were administered in a total of 10 ml of normal saline at the conclusion of the surgery, just before the neuromuscular blockade was inverted. We looked at how often patients threw up in the first 6, 12, and 24 hours after surgery. The data were evaluated using SPSS version 20. Statistical significance was achieved when the p-value was less than 0.05. Results: Patients treated with ondansetron had a 75% full response rate, whereas those treated with granisetron had an 86% complete response rate (P<0.05). The data showed no statistical significant change in recovery time after surgery was found between the two medicines, and only a moderate difference in adverse events was seen. Conclusion: When used as a preventative measure before laparoscopic cholecystectomy, ondansetron was linked with a higher rate of postoperative nausea and vomiting (PONV) than granisetron.