Frequency of Thyroid Dysfunction in Women with Abnormal Uterine Bleeding
Background: Abnormal uterine bleeding is one of the major clinical presentation in the gynecology department. There is a wide range of implications of this condition affecting all age groups of females from menarche to menopause. It causes burden on finances in addition to compromising the quality of life of these females. In addition to other systemic symptoms, menstrual abnormality is one of the hallmarks of thyroid dysfunction. Objective: The objective of the study was to determine the frequency of thyroid dysfunction in women with abnormal uterine bleeding. Study Design: Cross sectional study. Settings: The study was conducted at gynecology outpatient department, Sir Ganga Ram Hospital, Lahore Pakistan. Duration: Six months from 15th March 2018 till 15th September 2018. Methodology: All the women presenting with abnormal uterine bleeding in outpatient department of Sir Ganga Ram Hospital fulfilling, the inclusion criteria were included in study. After explaining about the study, consent was obtained from the patient. Demographic details were recorded as well as detailed menstrual history with respect to onset, time duration, estimated amount and any other symptom related to it was obtained. Clinical examination including general physical signs, systemic, gynecological examination and thyroid gland examination was carried out. Blood samples were taken from all these patients with complete aseptic techniques and sent to hospital laboratory for serumT3(triiodothyronine), T4(thyroxine) and TSH (thyroid stimulating hormone) estimation. Data was collected on predesigned proforma. Results: Among the 300 women included in the study, mean age was 36.25+5.89 years, with minimum and maximum age as 18 and 45 years. The mean TSH in these females was 1.97+1.92µIU/ml with minimum and maximum level as 0.1µIU/ml and 7.73µIU/ml. Thyroid dysfunction was seen in 114(38%) of the females while in 186(62%) TSH was in normal range. As in 186(62%) females the TSH was normal. While 36(12%) cases had hypothyroidism and 78(26%) females had hyperthyroidism. Conclusion: It is concluded that there is increased frequency of thyroid dysfunction in women with abnormal uterine bleeding therefore thyroid function tests should be routinely carried out in the women presenting with this complaint.