Simulation Models for Comparison of Toxicities of Anticancer Drugs

  • Muhammad Adeel Lecturer, Department of Computer Sciences, National Textile University, Faisalabad Pakistan
  • Muhammad Khalid Associate Professor, Department of Clinical Oncology, Faisalabad Medical University, Allied Hospital, Faisalabad, Pakistan
  • Muhammad Asif Head Department of Computer Science, National Textile University, Faisalabad Pakistan
  • Muhammad Naeem Faisal Assistant Professor, Physiology, University of Agriculture, Faisalabad Pakistan
Keywords: Simulation modeling, Quality of lifeduring chemotherapy, Comparison of AC and TC, Clinical markers, Toxicity of anticancer drugs

Abstract

This retrospectivestudy presents simulation models foranalyzing toxicities of doxorubicin and docetaxel, bothin combination of cyclophosphamide (AC and TC). Itcomparedtheir side effectsduring postoperative chemotherapy of the treated Pakistani breast tumor patients. Between September 2015 and September 2017, patients out of 356 received TC (600 mg/m2 of cyclophosphamide, 75 mg/m2 of docetaxel) and 168received AC (600 mg/m2of cyclophosphamide,60 mg/m2 of doxorubicin). Using simulation and modeling the study presents two simulation models called SMG1SE, (Simulation Model for Side Effects listed in Group 1) and SMG2SE (Simulation Model for Side Effects listed in Group 2). SMG1SE shows drugs toxicity based on side effects, listed in group 1 including muscles pain, mild anemia, moderate anemia, blood transfusion, weight loss, and hands burning. SMG2SE shows toxicity basedon side effects, listed in group 2 including vomiting, change in taste, sores in throat, diarrhea, tiredness, and dizziness.At α=0.05, chi-squared test was used for statistical analysis.It was observed no significant difference between the percentagesof patientswith extreme tiredness, stability, mild anemia,vomiting, and diarrhea forP-valueremained>0.05. Though, AC(P-value<0.05)was found less toxic by 25.7%, 22.6%, 25.3%,20.8%,16.4%, and 12.4% and compared to TC for muscle pain,changes in taste, burning hands,moderate anemia, needing blood transfusion, and change in hemoglobin level, respectively, but TC was found less toxic by 32.5%, 26.3%, and 52.9% for weight loss,sores in throat and mouth, and dizziness respectively.At 24 months, AC remainedless toxic than TC.

Published
2019-08-06