Dose and Time Related Effects of Lindane (γ-Hexachlorocyclohexane) on Hair Growth in Rabbit
Background: One of the most effective 2nd line scabicidal agent lindane (γ -HCH) is still used in many countries. It is moderately hazardous and causes severe physiological dysfunction in various organ systems. Method: The effects of (γ -HCH) on hair growth of male orytolagus Cuniculus Rabbit was studied in variable doses of 5,10,15 and 25mg/kg body weight for short term (up to 14 days) and also long term (up to 30 days) exposure. In addition general conditions and also some hematoenzymatic parameters were recorded in unexposed and exposed (treated) animals. Results: There was gradual increase in loss of hair with increasing dose of Lindane. With 5mg/kg body weight mild hair loss in neck and trunk, 10mg/kg body weight mild patchy loss of hair in neck & trunk region, 15 mg/kg body weight marked patchy loss of hair in neck region & moderate patchy loss of hair in trunk region, 20mg/kg body weight patches of almost complete loss of hair all over the body was observed. In addition, dose and time related anorexia, diarrhea, behavioral changes (weakness, restlessness, excitement and hyperactivity), bleeding tendency (observed while taking blood) and enzymatic changes (significantly increased serum alkaline phosphatase and SGPT) were also observed. Conclusion: The pharmacological use of γ-HCH, even as a 2nd line scabicidal agent should be strictly banned owing to its toxic effect on various systems of body.